Yuzhou Chang

Yuzhou Chang

His/Him

I am joint post dos and interested in computational biology on spatial omics data modeling using graph signal processing techniques

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About Me

Hello! I am Yuzhou Chang, a postdoctoral researcher at the Immuno-Oncology Informatics Group with Dr. Qin Ma, Pelotonia Institute for Immuno-Oncology at The Ohio State University, and Beth Israel Deaconess Medical Center, Harvard Medical School with Dr. Sizun Jinag. My research spans the intersection of spatial omics, immuno-oncology, and computational biology.

Research Interests

  • Graph Signal Processing: Leveraging graph-based methods for spatial transcriptomics analysis.
  • Spatial Omics Data Analysis: Developing computational tools to study cell-cell communication and tissue architecture.
  • Immuno-Oncology Applications: Utilizing spatial transcriptomics for insights into tumor-immune interactions.
  • Gene Regulatory Network Inference: Advancing methodologies to decode gene regulation.

Education

  • Postdoctoral Research: Immuno-Oncology Informatics, OSU & Harvard Medical School (2024–present)
  • Ph.D.: Biomedical Sciences, The Ohio State University (2018–2023)
    • Advisors: Prof. Qin Ma, Prof. Zihai Li
    • Training: Statistical modeling, bioinformatics, and computational systems biology
  • B.E.: Biopharmaceutical, China Pharmaceutical University (2012–2016)

Professional Achievements

I am the developer of tools like SpaGFT, a novel framework for spatial omics analysis using Graph Fourier Transform, and RESEPT, a deep learning framework for tissue architecture identification. For a full list of my publications, please visit my Google Scholar or GitHub profiles.

Teaching & Mentorship

I have contributed as a guest lecturer in courses such as:

  • Analysis and Applications of Genome-Scale Data (BMI 8130), The Ohio State University
  • Applications of Machine Learning and Artificial Intelligence in Biomedical Informatics (BMI 8050)

Contact Information

  • Email: yuzhou.chang@osumc.educhang.1754@osu.eduychang13@bidmc.harvard.edu
  • GitHub: BMEngineeR
  • Office: 2255 Kenny Rd, Columbus, OH 43210, USA

I am excited to collaborate on advancing the frontiers of bioinformatics and spatial biology. Feel free to reach out!